Effects of metoclopramide on the mouse anterior pituitary during the estrous cycle

The symptoms of hyperprolactinemia in women mainly result from changes in the release of gonadotropins and the consequent repercussions on ovarian function. Metoclopramide is a hyperprolactinemic drug that is used as an antiemetic agent. In female mice, metoclopramide-induced hyperprolactinemia causes changes in the reproductive system, mainly in ovarian function and the endometrium. While there is extensive data regarding prolactin regulation and hyperprolactinemic states, the direct effects of metoclopramide on the morphological and functional aspects of pituitary cells remain unknown. Therefore we have evaluated the histomorphological and immunohistochemical changes in lactotrophs of female mice upon treatment with metoclopramide.